Integrative Cellular Biology and Bioinformatics – Müller lab @ Saarland University

New preprint: Repeated malaria exposure reprograms Vδ2+ γδT cell chromatin accessibility and immune function toward a reversible hyporesponsive state

Post author:muellerf
Post published:October 12, 2026
Post category:News

Together with the Jagannathan lab at Stanford University, we (Midhuna and Adam) explored how repeated malaria infections reshape the transcriptional regulation through the epigenome and function of Vδ2+ T cells.…

New Preprint: methylTFR: Quantification of transcription factor activity from DNA methylation

Post author:muellerf
Post published:October 5, 2026
Post category:News

We are excited to share our new preprint introducing methylTFR, an R package that infers transcription factor (TF) activity from DNA methylation. DNA methylation shapes where TFs bind and is…

New Preprint: Dissecting the epigenome dynamics in human immune cells upon viral and chemical exposure by multimodal single-cell profiling

Post author:muellerf
Post published:September 12, 2025
Post category:News

Together with the Greenleaf and Ecker labs, we characterize the multimodal epigenome and regulatory dynamics in human immune cells in response to pathogen exposure. Abstract:Pathogen and chemical exposures lead to…

Teaching: Computational Methods for Epigenome Analysis (2025)

Post author:muellerf
Post published:May 9, 2025
Post category:News

We will be teaching workshop (special lecture in bioinformatics (5 CPs)) on the practical analysis of epigenome data. WIn this workshop you will gather hands-on exprience in the analysis of…

Teaching: Single-Cell Bioinformatics

Post author:muellerf
Post published:September 24, 2024
Post category:News

We will be teaching a special lecture in bioinformatics (9 CPs) on the hot topic of computational methods for single-cell analyses. We will be covering methods and topics from the…

Job Opportunity

Post author:muellerf
Post published:September 4, 2024
Post category:News

Interested in a PhD or post-doc in bioinformatics? Eager to engage in cutting-edge research in computational epigenomics in a starting lab at Saarland University? Check out this opportunity! Job posting…

Functional Epigenomics Conference

Post author:muellerf
Post published:February 15, 2024
Post category:News

We are excited to be part of the organizing team for the "Functional Epigenomics Conference" (May 27-28, 2024) in Saarbrücken. Registration and Details can be found on the conference website.

Paper: Single-cell transcriptomic landscape of the developing human spinal cord

Post author:muellerf
Post published:April 25, 2023
Post category:News

Excited to share this article describing the single-cell transcriptional landscape of the developing human spinal cord. Great work led by Jimena Andersen and Nick Thom in the Pasca lab with…

Teaching: Computational Methods for Epigenome Analysis (2022)

Post author:muellerf
Post published:March 21, 2022
Post category:News

We will be teaching workshop (special lecture in bioinformatics (4 CPs)) on the practical analysis of epigenome data. WIn this workshop you will gather hands-on exprience in the analysis of…

New Preprint: Landscape of human spinal cord cell type diversity at midgestation

Post author:muellerf
Post published:January 3, 2022
Post category:News

New work led by Jimena Andersen and Nick Thom at Sergiu Pasca's lab in Stanford uncovers the diverse landscape of the developing human spinal cord and a surprisingly early diversification…